abstract：:Five quantitative histologic factors, differing linear combinations of 26 reliably recognized histologic features, account for much of the histologic variance in 1068 children with infratentorial neuroglial tumors in the Childhood Brain Tumor Consortium (CBTC) database. In this study, we used the scores on the Spongy,...

journal_title：Journal of neuro-oncology

authors： Gilles FH,Sobel EL,Leviton A,Tavaré CJ

更新日期：1998-08-01 00:00:00

abstract：:Since the introduction of CT and MRI as diagnostic aids, it has been possible to obtain direct images of neoplastic meningiosis. After more than ten years experience, the combination of MRI with the administration of a paramagnetic contrast medium is now accepted as the method of choice for the sensitive detection of ...

journal_title：Journal of neuro-oncology

authors： Schumacher M,Orszagh M

更新日期：1998-06-01 00:00:00

abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

journal_title：Journal of neuro-oncology

authors： Schmandt S,Kühl J

更新日期：1998-06-01 00:00:00

abstract：:The p21WAF1/Cip1 (p21) protein, a negative regulator of G1 checkpoint control, was overexpressed in the majority of human gliomas. To investigate whether p21 expression in brain metastases from various systemic origins is similar to that in gliomas and whether p21 expression is regulated differently in brain metastase...

journal_title：Journal of neuro-oncology

authors： Ruan S,Fuller G,Levin V,Bruner JM,Zhang W

更新日期：1998-05-01 00:00:00

abstract：:A 44 year-old man with subcutaneous meningioma and rare combination of spinal lesions, consisting of dermal sinus and lipoma of the filum terminale. The literature concerning the subcutaneous meningioma is reviewed and the embryogenesis of these lesions is discussed. ...

journal_title：Journal of neuro-oncology

authors： Qasho R,Lunardi P,Lo Bianco FM,di Stefano M

更新日期：1998-05-01 00:00:00

abstract：:Anaplastic mixed gliomas are rare tumors that occur mostly in the cerebral hemispheres. They have a distinctive histological appearance characterized by the presence of two or more glial cellular constituents. The incidence of malignant mixed glioma of the brainstem and posterior fossa is extremely low. The authors re...

journal_title：Journal of neuro-oncology

authors： Lee TT,Galarza M,Petito CK,Heros RC

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:Diffuse pontine tumors are highly lethal, and there are few long-term survivors with the standard treatment of external beam irradiation. We investigated the effectiveness of high-dose thiotepa and etoposide-based chemotherapy regimens with autologous bone marrow rescue (ABMR) in children with pontine tumors. ...

journal_title：Journal of neuro-oncology

authors： Dunkel IJ,Garvin JH Jr,Goldman S,Ettinger LJ,Kaplan AM,Cairo M,Li H,Boyett JM,Finlay JL

更新日期：1998-03-01 00:00:00

abstract：:To explore the antitumor mechanism of bacterial cytosine deaminase plus 5-fluorocytosine (CD/5-FCyt) in combination with interferons (IFNs), glioma cells were transduced with recombinant retroviruses expressing CD. The transduced glioma cells become sensitive to the nontoxic prodrug 5-FCyt. Apoptosis, DNA damage, byst...

journal_title：Journal of neuro-oncology

authors： Wang ZH,Samuels S,Gama Sosa MA,Kolodny EH

更新日期：1998-02-01 00:00:00

abstract：:To cast light on the mechanisms of drug-resistance, experimental brain tumors were immunohistochemically evaluated for expression of glutathione S-transferase (GST)-alpha, mu, pi, p-glycoprotein and apoptosis-related factors, such as bcl-2 and p53, as well as by the terminal deoxynucleotidyl transferase-mediated dUTP-...

journal_title：Journal of neuro-oncology

authors： Yabuno T,Konishi N,Nakamura M,Tsuzuki T,Tsunoda S,Sakaki T,Hiasa Y

更新日期：1998-01-01 00:00:00

abstract：:This study concerns the use of the MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide] colorimetric assay to evaluate the chemosensitivity of the C6 rat glioma cell line to a panel of twelve chemotherapeutic agents. In a previous study of in vitro chemosensitivity of human glioma cell lines, the pre...

journal_title：Journal of neuro-oncology

authors： Hand CM,Vender JR,Black P

更新日期：1998-01-01 00:00:00

abstract：:Nineteen patients with nervous system metastasis of hepatocellular carcinoma (HCC) were evaluated retrospectively. Nervous system metastasis was frequently initial presentation of HCC (seven out of 19 patients). Seven patients had metastases of the brain, of whom four had a stroke-like presentation. CT or MRI in these...

journal_title：Journal of neuro-oncology

authors： Kim M,Na DL,Park SH,Jeon BS,Roh JK

更新日期：1998-01-01 00:00:00

abstract：:The abilities of growth factors to cause normal cells to express the properties associated with transformed cells is discussed in specific reference to the oligodendrocyte-type-2 astrocyte (O-2A) progenitor cell. In the O-2A lineage, it has been possible to use growth factors and other defined molecules to induce or p...

journal_title：Journal of neuro-oncology

authors： Noble M,Mayer-Pröschel M

更新日期：1997-12-01 00:00:00

abstract：:The activation of autocrine loops involving proto-oncogene related receptor tyrosine kinases has led to the analysis of a large number of growth factor systems in human glioma specimens and cell lines. The ErbB-2 system, also called HER-2 or neu, is analogous to the epidermal growth factor receptor system (EGF-R, ErbB...

journal_title：Journal of neuro-oncology

authors： Westphal M,Meima L,Szonyi E,Lofgren J,Meissner H,Hamel W,Nikolics K,Sliwkowski MX

更新日期：1997-12-01 00:00:00

abstract：:Patients with locally advanced transitional cell carcinoma (TCC) of the bladder are at high risk for systemic relapse, with liver, bone and lung being the commonest sites of metastases. We report the case of a 52-year-old woman with a solitary meningeal relapse, a rare site of recurrence, after 8 months of complete re...

journal_title：Journal of neuro-oncology

authors： Santarossa S,Vaccher E,Balestreri L,Volpe R,Tirelli U

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Paclitaxel-induced peripheral neuropathy (PN) may be severe and dose-limiting at initial doses > or = 275 mg/M2, but its neurotoxicity at doses < or = 250 mg/M2 has been incompletely characterized. The purposes of this study were to characterize and quantify paclitaxel-induced PN and to determine the utility...

journal_title：Journal of neuro-oncology

authors： Forsyth PA,Balmaceda C,Peterson K,Seidman AD,Brasher P,DeAngelis LM

更新日期：1997-10-01 00:00:00

abstract：:Leptomeningeal carcinomatosis is a painful and debilitating complication of cancer. Indwelling reservoirs provide continuous assess to the subarachnoid space, making leptomeningeal cancer potentially amenable to gene therapy. Adeno-associated virus (AAV) is a defective virus not associated with any human disease. We u...

journal_title：Journal of neuro-oncology

authors： Rosenfeld MR,Bergman I,Schramm L,Griffin JA,Kaplitt MG,Meneses PI

更新日期：1997-09-01 00:00:00

abstract：:In a cohort of 25 patients with supratentorial low grade glioma, the timing of radiotherapy made no significance difference for 10 year survival. Patients who received early radiotherapy had a 55% 10 year survival and those receiving delayed radiotherapy had a 53% 10 year survival. Radiotherapy was delayed a median of...

journal_title：Journal of neuro-oncology

authors： Knisely JP,Haffty BG,Christopher SR

更新日期：1997-08-01 00:00:00

abstract：:Glioblastoma cells secrete transforming growth factor-beta (TGF-beta), which has a variety of immunosuppressive properties. We investigated the effect of irradiation TGF-beta secretion by malignant glioma cells. Three malignant glioma cell lines (T98G, A172, KG-1-C) were cultured and irradiated using 10 and 50 Gy Lina...

journal_title：Journal of neuro-oncology

authors： Satoh E,Naganuma H,Sasaki A,Nagasaka M,Ogata H,Nukui H

更新日期：1997-07-01 00:00:00

abstract：:High grade astrocytomas remain incurable even though these tumors often appear localized on modern imaging studies, rarely metastasize to systemic sites, and can be aggressively treated with surgery and radiation therapy. Recent data suggest that the dissemination of astrocytoma cells along white matter tracts to dist...

journal_title：Journal of neuro-oncology

authors： Geer CP,Grossman SA

更新日期：1997-05-01 00:00:00

abstract：:The stable isotope 10B has a peculiarly marked avidity to capture slow neutrons whereupon it disintegrates into a lithium and a helium atom. These give up the 2.4 MeV of disintegration energy which they share within 5 and 9 microns of the 10B atom respectively. This means that the cell closest to the 10B atom bears th...

journal_title：Journal of neuro-oncology

authors： Sweet WH

更新日期：1997-05-01 00:00:00

abstract：:To determine binding and distribution of Na2B12H11SH (BSH) in glioma tissue in case of boron neutron capture therapy, an antibody to this compound was produced and used in immunohistochemical investigations. It is possible to trace BSH in immunohistochemistry, because BSH is firmly bound to the glioma tissue. The anti...

journal_title：Journal of neuro-oncology

authors： Otersen B,Haritz D,Grochulla F,Bergmann M,Sierralta W,Gabel D

更新日期：1997-05-01 00:00:00

abstract：:A high affinity folate receptor is expressed in some human cancers, including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. In this report, the expression of folate receptors in an SV40 large T antigen transgenic mouse (SV11) was investigated. SV11 mice develop choroid ple...

journal_title：Journal of neuro-oncology

authors： Patrick TA,Kranz DM,van Dyke TA,Roy EJ

更新日期：1997-04-01 00:00:00

abstract：:We have investigated the anti-tumor activity of ex vivo activated and expanded T cells which had been sensitized in vivo to one of two different syngeneic rat glioma cell lines; D74 or RT-2. Rats were sensitized by inoculation of irradiated tumor cells into each hind foot pad. After 10 days, the tumor-draining lymph n...

journal_title：Journal of neuro-oncology

authors： Rice CD,Baldwin NG,Biron RT,Bear HD,Merchant RE

更新日期：1997-03-01 00:00:00

abstract：:There is considerable interest in the role of the TRK family of neurotrophin receptors in regulating the survival, growth and differentiation of normal and neoplastic nerve cells. Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors o...

journal_title：Journal of neuro-oncology

authors： Brodeur GM,Nakagawara A,Yamashiro DJ,Ikegaki N,Liu XG,Azar CG,Lee CP,Evans AE

更新日期：1997-01-01 00:00:00

abstract：:When SK-N-BE(2) human neuroblastoma cells were exposed for 1h to growth medium supplemented with [14C]arachidonic acid (AA) at final concentrations ranging from 1 microM to 100 microM, an amount of this fatty acid was uptaken ranging form a 2% to a 120% of that present in cells at steady state. As more [14C]AA was upt...

journal_title：Journal of neuro-oncology

authors： Spinedi A

更新日期：1997-01-01 00:00:00

abstract：:Neuroblastoma (NB) is a tumor of pediatric age that is associated with high mortality in metastatic stages, although stage IVS patients undergo frequent spontaneous regression. Since apoptosis has been proposed as a possible cause of remission among cancer patients, we tested this hypothesis among both localized and m...

journal_title：Journal of neuro-oncology

authors： Tonini GP,Mazzocco K,di Vinci A,Geido E,de Bernardi B,Giaretti W

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:The poor results from treatment of high grade glioma prompted us to explore new protocols involving concurrent radio-chemotherapy. Our primary objective was to evaluate the feasibility of very early postoperative chemotherapy with BCNU, concurrent radio-chemotherapy with carboplatin and teniposide, and post-rad...

journal_title：Journal of neuro-oncology

authors： Brandes AA,Rigon A,Zampieri P,Scelzi E,Amistà P,Berti F,Rotilio A,Gardiman M,Fiorentino MV

更新日期：1996-12-01 00:00:00

abstract：:A rat glioma model was employed to estimate the Ca2+ kinetics in the tumor arteriolar smooth muscle cells. Electron microcytochemistry revealed that the density of intracellular Ca2+ deposits in the intra-tumor arteriolar smooth muscle cells was significantly greater, with slightly higher membrane Ca(2+)-adenosine tri...

journal_title：Journal of neuro-oncology

authors： Zenke K,Nakagawa K,Kumon Y,Ohta S,Hatakeyama T,Sakaki S

更新日期：1996-10-01 00:00:00

abstract：:Meningiomas of the anterior skull base account for 40% of all intracranial meningiomas. Of these, almost half are sphenoid wing meningiomas; the other half are tuberculum sella tumors or olfactory groove tumors. Anterior clinoidal (medial sphenoid wing) meningiomas are a subcategory of the sphenoid wing meningiomas; t...

journal_title：Journal of neuro-oncology

authors： DeMonte F

更新日期：1996-09-01 00:00:00

abstract：:Recurrent gliomas are most often treated by chemotherapy. However, these tumors typically acquire resistance to most drugs administered, and patients will usually die of recurrent tumor. Factors which may play a role include overexpression of putative multidrug resistance genes, such as the multidrug resistance gene 1...

journal_title：Journal of neuro-oncology

authors： Liang BC

更新日期：1996-08-01 00:00:00

abstract：:When a malignant tumor invades the child's cerebellum, the cost of successful treatment is often significant cognitive morbidity. A review of neuropsychological outcome revealed that survivors of childhood medulloblastoma (MB) have long-term deficits in intelligence, memory, language, attention, academic skills, psych...

journal_title：Journal of neuro-oncology

authors： Dennis M,Spiegler BJ,Hetherington CR,Greenberg ML

更新日期：1996-07-01 00:00:00

abstract：:The treatment of visual pathway gliomas is controversial. The many retrospective studies reporting outcome data for patients with chiasmatic/hypothalamic gliomas are difficult to interpret for several reasons. First the natural history of these tumors is erratic with some reports suggesting that most visual pathway gl...

journal_title：Journal of neuro-oncology

authors： Garvey M,Packer RJ

更新日期：1996-05-01 00:00:00

abstract：:Long term survival is rare in patients with glioblastoma multiforme (GBM). To determine if the tumors of patients with long survivals constitute a subgroup of patients with identifiable molecular genetic characteristics, we studied the p53 gene and Epidermal Growth Factor Receptor (EGF-R) expression in long-term survi...

journal_title：Journal of neuro-oncology

authors： Morita M,Rosenblum MK,Bilsky MH,Fraser RA,Rosenfeld MR

更新日期：1996-03-01 00:00:00

abstract：:From 1974 to 1992, 63 patients diagnosed with low-grade pure or mixed oligo-astrocytoma were seen and treated at our institution. All patients underwent CT scan pre-operatively. There were 20 female and 43 males ranging in age from 12 to 73 years (median age of 33 years). 15 patients had a stereotactic biopsy as the o...

journal_title：Journal of neuro-oncology

authors： Bahary JP,Villemure JG,Choi S,Leblanc R,Olivier A,Bertrand G,Souhami L,Tampieri D,Hazel J

更新日期：1996-02-01 00:00:00

abstract：:We studied the effect of intracarotid infusion of various calcium antagonists on regional CBF (rCBF) in the C6 rat glioma by a hydrogen clearance method. Nimodipine at doses of 0.1, 0.5 and 1 microgram/kg/min was found to produce tumor-specific increases in the rCBF (40.2 +/- 18.4%, p < 0.01, 67.8 +/- 32.6%, p < 0.001...

journal_title：Journal of neuro-oncology

authors： Matsukado K,Ikezaki K,Nomura T,Fukui M

更新日期：1996-01-01 00:00:00

abstract：UNLABELLED:Cranio-spinal irradiation is the gold standard treatment used in non metastatic medulloblastoma as prophylaxis against central nervous system (CNS) metastases. However, given the severe late effects caused by this procedure in children under 3 years of age, most pediatric oncologists are currently treating t...

journal_title：Journal of neuro-oncology

authors： Dupuis-Girod S,Hartmann O,Benhamou E,Doz F,Mechinaud F,Bouffet E,Coze C,Kalifa C

更新日期：1996-01-01 00:00:00

abstract：:Our laboratory and others have shown alternative splicing of up to ten exons at a discrete extracellular site to be primarily responsible for the generation of CD44 variant (CD44v) isoforms. Based on clear differences in the expression of these CD44v isoforms between normal and malignant tissues, we believe that eluci...

journal_title：Journal of neuro-oncology

authors： Asman DC,Dirks JF,Ge L,Resnick NM,Salvucci LA,Gau JT,Becich MJ,Cooper DL,Dougherty GJ

更新日期：1995-12-01 00:00:00

abstract：:p53 mutations are the most frequently detected genetic alterations of gliomas, appearing in a similar proportion of low and high grade astrocytomas, while the amplification of epidermal growth factor receptor (EGFR) gene appears mainly in glioblastomas. Thus, these changes seem to delineate two subgroups of high grade...

journal_title：Journal of neuro-oncology

authors： Kordek R,Biernat W,Alwasiak J,Maculewicz R,Yanagihara R,Liberski PP

更新日期：1995-10-01 00:00:00

abstract：:We report the case of a 58 year old woman with an epidermoid cyst of the right cerebello-pontine angle that was subtotally excised. She recurred 2 years later and received radiotherapy with resolution of symptoms and shrinkage of the cyst. The natural history of epidermoid cysts and the role of radiotherapy in their m...

journal_title：Journal of neuro-oncology

authors： Parikh S,Milosevic M,Wong CS,Laperriere N

更新日期：1995-01-01 00:00:00

abstract：:Approximately 200,000 men will be diagnosed with prostate cancer in 1994. While localized disease is potentially curable with surgery or radiation therapy, metastatic disease is incurable. The most frequent site of metastasis is bone. Spinal cord compression occurs in approximately 7% of men with prostate cancer. Back...

journal_title：Journal of neuro-oncology

authors： Osborn JL,Getzenberg RH,Trump DL

更新日期：1995-01-01 00:00:00